Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and links to their rpeorts go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 2300
interventional 1158
Observational 1064
Registry 78

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 254
Behavioral 211
Device 146
Other 118
Drug|placebo 107
Procedure 102
Behavioral|Drug 22
Diagnostic Test 20
Dietary Supplement 20
Biological 18
Drug|Procedure 16
Behavioral|Other 12
Dietary Supplement|placebo 12
Device|Drug 11
Drug|Other 10
Device|Other 9
Device|Procedure 7
Other|Procedure 7
Drug|Other|placebo 4
Behavioral|Device 3
Behavioral|Drug|placebo 3
Behavioral|Drug|Procedure 3
Behavioral|Procedure 3
Biological|placebo 3
Device|Drug|Procedure 3
Genetic 3
Behavioral|Dietary Supplement 2
Behavioral|Drug|Other 2
Diagnostic Test|Drug 2
Drug|placebo|Procedure 2
Other|placebo 2
Radiation 2
Behavioral|Biological|Drug 1
Behavioral|Device|Drug 1
Behavioral|Device|Other 1
Behavioral|Dietary Supplement|Other 1
Behavioral|Genetic 1
Behavioral|Genetic|Other 1
Biological|Device|Genetic|Procedure 1
Biological|Device|placebo 1
Biological|Drug 1
Biological|Other|placebo 1
Biological|Procedure 1
Combination Product 1
Combination Product|Device 1
Combination Product|Drug|placebo 1
Device|Other|Procedure 1
Device|Radiation 1
Diagnostic Test|Other 1
Dietary Supplement|Other 1
placebo|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 332
NA 234
Canada 65
China 61
United Kingdom 46
Denmark 45
Germany 35
France 32
Brazil 22
Korea, Republic of 22
Sweden 16
Norway 13
Italy 12
Spain 12
Russian Federation 11
United States|Canada 11
Switzerland 10
Belgium 9
Egypt 8
Netherlands 8
Finland 7
Israel 7
Poland 7
Taiwan 7
India 6
Japan 6
Australia 5
Austria 2
Denmark|Sweden 2
Ecuador 2
France|Germany|Italy 2
Hong Kong 2
Indonesia 2
Iran, Islamic Republic of 2
Malaysia 2
Mexico 2
Pakistan 2
Portugal 2
Singapore 2
Slovenia 2
Thailand 2
Turkey 2
United States|Canada|Korea, Republic of 2
United States|Germany 2
Argentina 1
Argentina|Australia|Belgium|Croatia|France|Germany|Italy|Netherlands|Norway 1
Argentina|Bolivia|Brazil|Colombia|El Salvador 1
Austria|Belgium|United States|Argentina|Australia|Brazil|Canada|China|Czechia|Denmark|Finland|France|Germany|Grenada|Hungary|Ireland|Israel|Italy|Korea, Republic of|Netherlands|New Zealand|Poland|Puerto Rico|Slovakia|South Africa|Spain|Sweden|Switzerland|United Kingdom 1
Austria|France|Germany|Italy|Netherlands|Switzerland|United Kingdom 1
Austria|Germany|Switzerland 1
Austria|Netherlands|New Zealand 1
Belgium|Canada 1
Belgium|Denmark|Estonia|Finland|Germany|Ireland|Italy|Latvia|Netherlands|Norway|Poland|Sweden|United Kingdom 1
Belgium|Denmark|Finland|France|Germany|Hungary|Italy|Netherlands|Poland|Portugal|Russian Federation|Saudi Arabia|South Africa|Spain 1
Belgium|Germany|Israel|Sweden 1
Belgium|Italy|Netherlands 1
Belgium|United Kingdom 1
Bolivia 1
Botswana|Brazil|Cameroon|China|Egypt|Ethiopia|India|Kazakhstan|Kenya|Kyrgyzstan|Malawi|Mexico|Mozambique|Nepal|Nigeria|Pakistan|Paraguay|Philippines|Rwanda|South Africa|Sudan|Tanzania|Uganda|Zambia|Zimbabwe 1
Canada|Germany 1
China|Germany|Netherlands 1
China|Hong Kong 1
China|United States|Argentina|Australia|Belgium|Brazil|Bulgaria|Canada|Chile|Czechia|Denmark|Estonia|France|Germany|Greece|Hong Kong|Hungary|India|Italy|Japan|Korea, Republic of|Mexico|Netherlands|New Zealand|Norway|Pakistan|Peru|Philippines|Poland|Romania|Russian Federation|Slovakia|South Africa|Spain|Sweden|Taiwan|Thailand|Ukraine|United Kingdom 1
Colombia 1
Czech Republic 1
Denmark|Estonia|Finland|France|Norway|Spain|Sweden|United Kingdom 1
Denmark|Finland|Iceland|Norway|Sweden 1
Denmark|Netherlands|Spain 1
Denmark|Netherlands|Spain|Sweden 1
Denmark|Poland 1
Finland|France|Germany|Italy|Netherlands|Poland|Spain|Switzerland|United Kingdom 1
France|Germany|Italy|Poland|Spain|Sweden|United Kingdom 1
Germany|Italy|Korea, Republic of|Netherlands|Spain|Turkey 1
Greece 1
Hong Kong|Taiwan 1
Hungary|Malaysia|Poland 1
Jordan 1
Lithuania 1
Mauritius 1
Nepal 1
Netherlands|United States|Argentina|Australia|Bulgaria|Canada|Czechia|Denmark|France|Germany|Hungary|Italy|Korea, Republic of|Poland|Russian Federation|Spain|Sweden|Taiwan|United Kingdom 1
Palestinian Territory, occupied 1
Poland|United States|Australia|Canada|China|Czech Republic|Denmark|France|Hungary|Mexico|Netherlands|Spain|United Kingdom 1
Saudi Arabia 1
South Africa 1
Spain|United States|Argentina|Australia|Bulgaria|Canada|Denmark|Estonia|France|Germany|Hungary|India|Netherlands|New Zealand|Pakistan|Romania 1
Spain|United States|Australia|Austria|Belgium|Canada|France|Germany|Ireland|Italy|Netherlands|South Africa|Switzerland|United Kingdom| 1
Sri Lanka 1
Uganda 1
Ukraine 1
United States|Argentina|Australia|Austria|Belgium|Brazil|Canada|China|Egypt|France|Germany|Hungary|India|Israel|Italy|Japan|Lithuania|Malaysia|Mexico|Netherlands|New Zealand|North Macedonia|Peru|Poland|Portugal|Romania|Russian Federation|Saudi Arabia|Serbia|Singapore|South Africa|Spain|Sweden|Switzerland|Taiwan|Thailand|United Kingdom 1
United States|Argentina|Australia|Austria|Brazil|Canada|Finland|France|Germany|Israel|Italy|Mexico|Russian Federation|Spain|United Kingdom 1
United States|Argentina|Brazil|Canada|Georgia|Russian Federation 1
United States|Australia|Belgium|Brazil|Canada|Czechia|Denmark|Ireland|Israel|Italy|Korea, Republic of|Netherlands|New Zealand|Portugal|Spain|United Kingdom 1
United States|Australia|Belgium|Canada|Denmark|Germany|Hungary|Israel|Korea, Republic of|Netherlands|New Zealand|Spain|Switzerland 1
United States|Australia|Brazil|Canada|China|Czechia|Denmark|France|Germany|Ireland|New Zealand|Poland|Taiwan|United Kingdom 1
United States|Australia|China|Czechia|Denmark|France|Poland|United Kingdom 1
United States|Austria|Belgium|Bulgaria|Canada|Czech Republic|Denmark|France|Germany|Hungary|Israel|Lebanon|Poland|Russian Federation|Spain|Sweden|United Kingdom 1
United States|Austria|Canada|China|Croatia|Germany|Italy|Japan|Korea, Republic of|Netherlands|Portugal|Serbia|Singapore 1
United States|Austria|Canada|Croatia|Egypt|France|Hungary|India|Israel|Lebanon|Spain|Turkey|Ukraine|United Kingdom 1
United States|Belgium|Canada|Netherlands|Poland|Spain 1
United States|Belgium|Denmark|Israel|Netherlands|South Africa|United Kingdom 1
United States|Brazil|Canada|Czechia|Italy 1
United States|Brazil|Canada|Denmark|Germany|Japan|Netherlands|Singapore 1
United States|Canada|China 1
United States|Canada|Czech Republic|Germany|Hungary|New Zealand|Norway|Slovakia|South Africa 1
United States|Canada|Czech Republic|Germany|South Africa|United Kingdom 1
United States|Canada|France 1
United States|Canada|Japan 1
United States|Canada|Mexico 1
United States|Colombia 1
United States|Czechia|Netherlands|United Kingdom 1
United States|Denmark|Germany|Israel|Netherlands 1
United States|France|Greece|Poland|United Kingdom 1
United States|Germany|Ireland 1
United States|Germany|Netherlands|New Zealand 1
United States|United Kingdom 1
Venezuela 1
Venezuela|United States|Argentina|Brazil|Chile|Colombia|Lithuania|Netherlands|Peru 1

Sites per Study

Site_count Study_Count
1 909
2 64
3 29
4 12
5 17
6 6
7 6
8 4
9 9
10 8
11 3
12 8
13 5
14 2
15 2
16 7
17 6
18 2
19 4
20 3
22 1
23 3
24 2
27 2
28 2
29 1
30 2
31 1
33 1
34 2
38 1
39 1
41 1
45 1
46 1
47 1
48 1
51 1
54 1
55 1
57 1
62 1
64 1
73 1
80 1
81 1
82 1
91 1
92 1
102 1
119 1
120 1
124 1
147 1
153 1
157 1
159 1
177 1
241 1
270 1
314 1
320 1
471 1
651 1
1091 1

Phase

Phase Study_Count
N/A 594
Phase 3 229
Phase 4 129
Phase 2 117
Phase 1 43
Phase 2/Phase 3 19
Phase 1/Phase 2 17
Early Phase 1 10

Number of Arms

Number_of_Arms Count_of_Studies
1 182
2 587
3 106
4 33
5 5
6 10
11 1
NA 234

Number of Updates

Count of Versions Count of Studies
1 102
2 158
3 234
4 170
5 103
6 91
7 62
8 48
9 38
10 32
11 16
12 11
13 13
14 12
15 7
16 10
17 7
18 3
19 3
20 2
21 2
22 4
24 1
26 3
28 1
29 2
31 1
32 1
34 1
36 2
37 1
38 1
40 1
55 1
56 2
57 1
60 1
71 1
73 1
77 1
79 1
80 1
88 1
91 1
97 1
98 1
166 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 6123 1056 5.798296
Contacts/Locations 2430 791 3.072061
Recruitment Status 1360 801 1.697878
None (earliest Version on record) 1158 1158 1.000000
Study Design 1114 675 1.650370
Outcome Measures 838 489 1.713701
Study Identification 771 458 1.683406
Study Description 710 444 1.599099
Sponsor/Collaborators 696 466 1.493562
Arms 693 439 1.578588
Interventions 693 439 1.578588
Eligibility 600 395 1.518987
Oversight 443 348 1.272989
References 385 252 1.527778
Conditions 209 169 1.236686
Results 144 144 1.000000
More Information 139 80 1.737500
IPDSharing 99 94 1.053192
Baseline Characteristics 50 43 1.162791
Results Submission Events 46 46 1.000000
Participant Flow 31 27 1.148148
Reported Adverse Events 30 30 1.000000
Documents 22 18 1.222222
2020 Outcome Measures 2 1 2.000000
Quality Control Review has not concludedReturned: June 17 1 1 1.000000
Quality Control Review has not concludedReturned: May 27 1 1 1.000000

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 5.0 1.0000 5.0000 17.00000 6.0000 18.0000 3.000 2.0000
1st Qu. 20.0 48.5000 20.2500 26.00000 40.0000 49.5000 120.000 60.0000
Median 26.0 117.0000 33.5000 36.00000 90.0000 100.0000 255.000 130.0000
Mean 28.0 794.5617 285.7619 59.41176 285.7079 129.2105 1473.861 623.5039
3rd Qu. 36.5 300.0000 90.0000 62.00000 216.0000 175.0000 902.000 441.0000
Max. 50.0 100000.0000 8400.0000 176.00000 8727.0000 375.0000 39876.000 8709.0000

Trial Group Type

group_type Group_Count
Experimental 859
Active Comparator 516
NA 234
Placebo Comparator 210
No Intervention 162
Other 136
Sham Comparator 19

Intervention Model

intervention_model Study_Count
Parallel Assignment 699
Single Group Assignment 233
NA 122
Crossover Assignment 61
Factorial Assignment 32
Sequential Assignment 11

Primary Purpose

primary_purpose Study_Count
Treatment 579
Prevention 278
Diagnostic 86
Supportive Care 53
Basic Science 44
Other 38
Health Services Research 35
NA 27
Screening 12
Device Feasibility 5
Educational/Counseling/Training 1

Observational Studies

Studies by Country

Country Study_Count
NA 566
United States 199
China 29
France 29
Germany 29
Korea, Republic of 20
United Kingdom 19
Canada 13
Italy 12
Belgium 10
Switzerland 10
Norway 9
Israel 8
Sweden 8
Austria 7
United States|Canada 7
Denmark 6
Russian Federation 6
Singapore 5
Spain 5
Brazil 4
Egypt 4
Poland 4
Finland 3
India 3
Japan 3
Netherlands 3
Croatia 2
United States|Australia 2
United States|United Kingdom 2
Austria|Belgium|Denmark|France|Germany|Hungary|Ireland|Italy|Netherlands|Spain|United Kingdom 1
Austria|Belgium|France|Germany|Italy|Norway|Poland|Slovenia|Spain|United Kingdom 1
Austria|Czech Republic|Germany|Switzerland|United Kingdom 1
Austria|Germany 1
Bangladesh 1
Belgium|Czechia|Germany|Italy|Netherlands|United Kingdom 1
Belgium|France|Germany|Greece|Ireland|Italy|Netherlands|Spain|Sweden 1
Belgium|France|Germany|Hungary|Ireland|Italy|Latvia|Poland|Spain|United Kingdom 1
Belgium|France|Germany|Italy|Switzerland 1
Belgium|Germany|Ireland|Italy|Switzerland 1
Belgium|Singapore 1
Brazil|Germany|Italy|United Kingdom 1
Bulgaria 1
Czech Republic 1
Czechia|France|Germany|Italy|Netherlands|United Kingdom 1
Ecuador 1
Fiji|New Caledonia|United Kingdom 1
Germany|India|Sri Lanka 1
Germany|Italy|Portugal|Spain 1
Greece 1
Hong Kong 1
Hungary 1
Kenya 1
Nicaragua 1
Nigeria|Uganda 1
Peru|Switzerland 1
Portugal 1
Puerto Rico 1
Qatar 1
Spain|Sweden 1
Taiwan 1
Turkey 1
United States|Argentina|Australia|Belgium|Canada|France|India|Italy|Japan|Malta|Netherlands|Norway|Sweden|Switzerland|Taiwan 1
United States|Australia|Belgium|Canada|Denmark|France|Germany|Hong Kong|Ireland|Italy|Netherlands|Spain|United Kingdom 1
United States|Austria|Belgium|Canada|France|Germany|Italy|Poland|Spain|Switzerland|United Kingdom 1
United States|Nigeria|Thailand 1
Zambia 1

Sites per Study

Site_count Study_Count
1 948
2 38
3 9
4 13
5 10
6 6
7 5
8 1
9 3
10 4
12 2
13 2
14 3
15 1
16 1
17 3
23 1
24 1
25 1
29 1
32 1
33 1
37 2
40 2
43 1
47 1
80 1
88 1
183 1

Number of Updates

Count of Versions Count of Studies
1 83
2 199
3 391
4 137
5 73
6 31
7 28
8 26
9 15
10 12
11 12
12 8
13 5
14 3
15 2
16 4
17 3
18 1
19 4
20 1
21 3
22 1
23 1
24 2
25 2
30 2
31 1
34 1
36 1
45 1
47 1
55 1
83 2
97 1
119 1
124 1
142 1
157 1
170 1
527 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 4947 981 5.042814
None (earliest Version on record) 1064 1064 1.000000
Study Description 1046 448 2.334821
Study Identification 1011 642 1.574766
Study Design 944 622 1.517685
Contacts/Locations 888 452 1.964602
Eligibility 745 596 1.250000
Recruitment Status 737 539 1.367347
Sponsor/Collaborators 477 371 1.285714
References 363 208 1.745192
Outcome Measures 306 232 1.318966
Oversight 270 234 1.153846
Groups 187 139 1.345324
Interventions 187 139 1.345324
Conditions 124 88 1.409091
IPDSharing 53 52 1.019231
More Information 18 11 1.636364
Results 18 18 1.000000
Results Submission Events 11 11 1.000000
Documents 5 5 1.000000
Baseline Characteristics 4 4 1.000000
Reported Adverse Events 4 4 1.000000
Participant Flow 3 3 1.000000

Enrollment Metrics

Measure Observational
Min 1.0
1st Qu 89.5
Median 314.0
Mean 225022.3
3rd Qu 1500.0
Max 99999999.0

Observation Model

observational_model Study_Count
NA 483
Cohort 371
Case-Only 68
Case-Control 41
Case Control 33
Other 28
Family-Based 12
Ecologic or Community 10
Case-Crossover 6
Defined Population, Natural History 6
Defined Population 3
Natural History 3

Time Perspective

time_perspective Study_Count
NA 443
Prospective 422
Retrospective 93
Cross-Sectional 86
Other 10
Longitudinal, Prospective 5
Longitudinal, Retrospective/Prospective 2
Cross-Sectional, Prospective 1
Cross-Sectional, Retrospective 1
Longitudinal, Retrospective 1

Registries

Studies by Country

Country Study_Count
NA 11
China 10
France 7
United States 6
Italy 4
Korea, Republic of 3
Austria 2
Belgium 2
Egypt 2
Germany 2
Hong Kong 2
Netherlands 2
Russian Federation 2
Spain 2
Switzerland 2
Austria|Germany 1
Brazil 1
Canada 1
Colombia 1
Denmark 1
France|Germany|Italy|Lithuania|Switzerland 1
Greece 1
Israel 1
Netherlands|Poland|Spain|United Kingdom 1
Norway 1
Portugal|Spain 1
Rwanda 1
Singapore 1
Thailand 1
United States|Australia|Canada|China|India|Korea, Republic of|Nepal|Russian Federation|Saudi Arabia|Ukraine 1
United States|Austria 1
United States|Canada|Germany|Israel 1
United States|Canada|United Kingdom 1
United States|Israel 1

Sites per Study

Site_count Study_Count
1 58
2 1
3 3
4 3
6 1
7 1
10 1
13 1
16 1
18 1
20 1
22 1
28 1
36 1
44 1
59 1
67 1

Number of Updates

Count of Versions Count of Studies
1 22
2 18
3 5
4 15
5 3
6 2
7 2
8 2
9 3
11 1
12 3
14 1
28 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 227 56 4.053571
Contacts/Locations 98 39 2.512821
None (earliest Version on record) 78 78 1.000000
Recruitment Status 47 35 1.342857
Study Description 37 19 1.947368
Study Design 34 22 1.545454
Outcome Measures 17 13 1.307692
Eligibility 16 14 1.142857
Study Identification 13 12 1.083333
Oversight 11 10 1.100000
Groups 10 9 1.111111
Interventions 10 9 1.111111
Conditions 7 6 1.166667
References 6 5 1.200000
Sponsor/Collaborators 6 6 1.000000
IPDSharing 4 4 1.000000
Documents 2 1 2.000000
Results 1 1 1.000000
Results Submission Events 1 1 1.000000

Enrollment Metrics

Measure Registries
Min 1.0
1st Qu 150.0
Median 645.0
Mean 107744.4
3rd Qu 2000.0
Max 5940299.0

Registry Model

observational_model Study_Count
Cohort 58
Case-Only 12
Case-Control 5
Other 3

Time Perspective

time_perspective Study_Count
Prospective 70
Cross-Sectional 4
Other 3
Retrospective 1

Follow-up

target_duration Study_Count
5 Years 11
2 Years 10
1 Year 9
10 Years 6
12 Months 6
1 Day 5
24 Months 4
3 Years 3
6 Months 3
1 Month 2
2 Months 2
20 Years 2
3 Months 2
10 Days 1
15 Months 1
15 Years 1
17 Years 1
18 Years 1
2 Days 1
3 Days 1
36 Months 1
4 Weeks 1
4 Years 1
6 Years 1
7 Days 1
9 Months 1